As of March 2025, Durham, North Carolina does not have specific short-term rental (STR) regulations that differentiate between owner-occupied and non-owner-occupied properties23. However, there are general rules and responsibilities that apply to all rental properties in Durham, including short-term rentals:

1. Compliance with Housing Code: All rental properties, including non-owner-occupied STRs, must meet the standards outlined in the City of Durham's Minimum Housing Code34.
2. Occupancy Limits: Typically, occupancy is limited to 2 people per bedroom plus 2 additional guests35.
3. Proactive Rental Inspection Program (PRIP): All residential rental properties in Durham, including STRs, fall under this program. Properties with 3 or more Minimum Housing Code violations in the prior year must register with the Department of Neighborhood Improvement Services34.
4. Business Registration: Hosts must register their short-term rental as a business with the Durham County Tax Administration4.
5. Tax Collection: Hosts are responsible for collecting and remitting state sales tax (4.75%) and Durham County's room occupancy tax (6%) on all short-term rental income24.
6. Zoning Compliance: While there are no specific zoning laws for STRs, hosts should ensure their property's use complies with the neighborhood's zoning designation4.
7. Noise Ordinances: STR operators must adhere to local noise ordinances, especially after 10 PM3.